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KMID : 1201420130060020067
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Journal of Neurocritical Care
2013 Volume.6 No. 2 p.67 ~ p.74
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Current Status and Perspectives of Stroke-Related Biomarker Research
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An Se-A
Kim Ok-Joon
Oh Seung-Hun
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Abstract
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Bood biomarkers can be a complementary for diagnosis, prognosis, and the therapeutic monitoring of novel treatments in ischemic stroke. Several candidate markers that are related to the biological pathway during cerebral ischemia have been investigated for clinical application, including neuronal markers, astroglial markers, inflammatory mediators, thrombosis/hemostasis-related markers, and bloodbrain barrier related markers. No single blood marker has been proven to be clinically useful to diagnosis stroke due to small sample size, variable time points of sampling, heterogeneous study design, and lack of strict controlling of stroke-mimic control in previous studies. Panel biomarker with combination of several candidate blood biomarkers would enhance the predictive power of single blood marker for diagnosis and prognosis of stroke. New advanced techniques, such as microarray technique for gene expression or proteomic technique, are currently available and may be helpful to screen useful biomarkers for stroke outcome. Future studies including large-scaled cohort with strict methodological design are needed for clinical application of blood biomarker-based diagnostic approach in stroke.
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KEYWORD
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Stroke , Biomarker , Blood , Clinical application
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